I uploaded a video this week about the possible link between senescent cells and arthritis. Injury can generate senescent cells. Injury can make cause (or at least increase) osteoarthritis. So could that be the mechanism? Could senescent cells be causing or exacerbating osteoarthritis? I’m not the first to think so. This paper from 2017 shows how a drug to kill senescent cells in mice helped with arthritis. But, unfortunately, the drug didn’t work in people as of 2020.
This got me thinking of arthritis and “high-heel socks.” So I made this comic in collaboration with an artist. I’m very glad Snowman was available to do the art again. They do wonderful work.