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I posted two videos over on PeterAllenWrites, both are about Antibody Drug Conjugates. In the papers I talk about, the idea is to attach a very toxic drug to an antibody. The antibody can carry the drug into specific, targeted cells. In these papers, the targets were senescent cells, the half-dead cells that cause some of the symptoms of aging. If we could remove these cells specifically, we could reverse aging to some degree.

The first paper (Poblocka et al) showed that antibodies with these drugs could kill senescent cells in a dish (Video 1). The second one (Takaya et al) showed that they could kill senescent cells in a mouse (Video 2). That represents a lot of progress between 2021 and 2023. But mice are not people. We still have a long way to go.

This post is available in video format, too!

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Why do I have to learn about DNA? Why is that required knowledge? I had a student – a graduate student, no less – ask me this, years ago. “Why do I have to learn THAT?” he said. Let’s talk about why learning about DNA (and science in general) is important. Let’s talk about Kevin.

This post is also a video! Check it out on YouTube.