Tag Archives: caffeine

nootropics, smart drugs, supplements and natural focus for medical students

It seems that medical students are using nootropics, or smart drugs (AKA brain enhancers, energy enhancers, focus, liquid nap, etc.). These things are supplements, prescription medications, and non-prescription gray-market pharmaceuticals which some literature suggests may make a person more able to perform academically. They make you “smarter,” but probably only some of them and probably only a little, and probably not really “smarter,” but rather more focused or attentive. And, of course, they all are supposed to be a lot better than good, old fashioned, cheap caffeine.

Some of the more common ones I’ve heard about are Adderall and Ritalin, both of which are (technically speaking) stimulants. I’ve heard anecdotes from people who have stayed up all night studying on amphetamines (highly illegal and not in the least recommended). The newer designer drugs like Provigil are becoming popular as well.

They all work a little differently. The stimulants tend to produce symptoms like OCD (obsessive compulsive disorder). In fact, even pseudoephedrine (Sudafed, cold medicine) can cause OCD-like impulses as a side effect. Psuedoephedrine is related to ephedrine, which can be harvested from the Ephedra plant which is now illegal as a dietary supplement (because it’s basically speed). Don’t be fooled, “natural” speed will cause as many problems as synthetic speed. I suspect that all those kids who can’t pay attention in class could be better served than inducing a low-level OCD compusion for studying, but that’s neither here nor there.

Provigil is a more targeted stimulant that shuts down the sleep/tiredness centers of the brain. No jitters, no OCD, and no urge to sleep at all. If you need to stay up, this is probably safer than high doses of caffeine. Why do you need a prescription? Eh, who knows, probably because doctors like to charge you a couple hundred for the privilege. Oh, and the pills cost about a buck a pop.

If you need to bone up on a subject quickly, you may be able to get your physician to prescribe any of the above (even speed, interestingly, though no reputable doctor would give that out as study aids). I’ve never acquired any of the above, but if I wanted Provigil I would complain of persistent tiredness that was interfering with my daily life and mention that I read about Provigil in Reader’s Digest.

OK, what about “natural” alternatives? Well, there are lots. I take cod liver oil since I don’t eat much fish and the omega fatty acids are supposedly good for me and (who knows) it might help my brain. It comes in totally benign little liqui-caps and it’s cheap. There are lots of others. They probably don’t work better than a placebo. But then, a placebo might be exactly what you need! So give them a try. Choline, Ginko, Dimethylaminoethanol (also known as DMAE) are all sold in health food stores and might be just the placebo you’re looking for.

There are also a bunch of unregulated compounds that the FDA has not forbidden or approved (as far as I know). They can be imported from outside the U.S. if you want to risk being the person that the government decides to make an example of. Adafinil Adrafinil is one that can be acquired that way, as well as Piracetam. Honestly, I would recommend against going that route, but hey, if you want to try unregulated pharmaceuticals from France, google up a batch and let me know how it goes!

In the next few hours if you got here looking for something right now, caffeine is probably the best bet. There are cheap pills and even caffinated mints available at your local pharmacy over the counter if you just can’t stand coffee.


Caffeine and Hallucinations

According to this little Science Blog post, caffeine has been linked to hallucinations. This was corroborated by (badly spelled) anecdotal evicence at the Lycaeum (only when dealing with “drug culture” does poor spelling adds to authenticity and credibility).  The original article (subscription required):


In diathesis–stress models of psychosis, cortisol released in response to stressors is proposed to play a role in the development of psychotic experiences. Individual differences in cortisol response to stressors are therefore likely to play a role in proneness to psychotic experiences. As caffeine has been found to increase cortisol response to a given stressor, we proposed that, when levels of stress were controlled for, caffeine intake would be related to hallucination-proneness and persecutory ideation. Caffeine intake, stress, hallucination-proneness and persecutory ideation were assessed by self-report questionnaires in a non-clinical sample (N = 219). Caffeine intake was positively related to stress levels and hallucination-proneness, but not persecutory ideation. When stress levels were controlled for, caffeine intake predicted levels of hallucination-proneness but not persecutory ideation. Implications of these findings are discussed and avenues for future research suggested.

Translation: There are chemicals that seem to be related to craziness and also to caffeine. It turns out that, among 200 people, the crazy ones drink a lot more coffee… we don’t think it’s a coincidence.

I took their questionnaire. At the end it referred me to intervoiceonline.org, The International Community for Hearing Voices.